Thermo-Efficient Strains of Variola Major Virus
نویسندگان
چکیده
منابع مشابه
Smallpox eradication. Destruction of variola virus stocks.
1. The global eradication of smallpox was confirmed in 1980 (resolution WHA33.3). From 1981 to 1986, WHO undertook a programme to implement the post-eradication policies contained in the 1979 report of the Global Commission for the Certification of Smallpox Eradication and endorsed by the Health Assembly in resolution WHA33.4. Progress was reviewed year by year from 1981 to 1984 by the WHO Comm...
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Immunization against smallpox (variola virus) with Dryvax, a live vaccinia virus (VV), was effective, but now safety is a major concern. To overcome this issue, subunit vaccines composed of VV envelope proteins from both forms of infectious virions, including the extracellular enveloped virion (EV) protein B5, are being developed. However, since B5 has 23 amino acid differences compared with it...
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After the recent summary of World Health Organization-authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the cause of the high mortality rate among pregnant women and whether ocular smallpox is partly the result of trachoma or vitamin A deficiency. The joi...
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In September 1975 Bangladesh was the only country in the world with endemic variola major, and the eradication of the disease was imminent. A rapid and accurate laboratory diagnostic method was required to supplement immunodiffusion in agar gel and culture on chorioallantoic membrane of embryonated egg available at the Institute of Public Health in Dacca, Bangladesh. To determine its effectiven...
متن کاملThe Origin of the Variola Virus
The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus. In the last century, smallpox was declared eradicated from the human community; however, the mechanisms responsible for the emergence of new dangerous ...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1967
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-1-3-379